You are an entrepreneur, hustler, or just curious about what is popping in the Dallas-Fort Worth startup scene.
You want to know who is killing it, who is solving real problems, and who is worth watching.
Maybe you are thinking, “Can I compete in this market? Are these startups legit, or just hype?”
No worries, I’ve got you.
This post breaks down 11 Dallas-Fort Worth startups making waves in 2025.
Real companies, real impact, no fluff.
From biotech to logistics, these businesses are solving problems and scaling fast.
Let’s get into it.
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Why Dallas-Fort Worth Is a Startup Hotbed
Dallas-Fort Worth (DFW) isn’t just cowboy boots and BBQ.
It’s a breeding ground for innovation.
Low living costs, a massive airport, and a business-friendly vibe make it a magnet for founders.
Venture capital in DFW jumped 66% from 2019 to 2020, and it’s still climbing.
Over 500 startup applications flood accelerators like Health Wildcatters every year.
This region has got the hustle, the talent, and the cash to fuel growth.
Here is who is leading the charge.
| Startup Name | Industry | What They Do | Key Highlight | Funding Raised (2025) |
|---|---|---|---|---|
| GenrAb | Biotech | Develops antibody therapies to protect brain cells from stress (e.g., MS, ALS) | Uses patient spinal fluid for research | $5.6M |
| Aerolane | Logistics | Builds AI-powered, electric cargo gliders for first/last-mile delivery | Cuts costs and emissions | Not specified |
| Veryable | Workforce Tech | Online marketplace connecting manufacturers with flexible workers | Like Uber for factory jobs | Not specified |
| Alto | Ridesharing | Luxury rideshare with employee-driven, all-electric fleets | Expanded beyond DFW | $45M (Series B) |
| StackPath | Cybersecurity | Provides enterprise security solutions like firewalls and SSL certificates | Serves over 1M customers | Not specified |
| Mercado Labs | Logistics | Cloud-based platform connecting suppliers, vendors, and logistics providers | Improves first-mile logistics | Not specified |
| Zyston | Cybersecurity | Strategic infosec solutions for Fortune 500 companies | Focus on human capital expertise | Not specified |
| ProsRent | Construction Tech | SaaS platform for construction equipment rentals | Won CodeLaunch 2016 | Not specified |
| Actuate Therapeutics | Healthtech | Develops treatments for high-impact cancers and neurodegenerative diseases | Innovative therapies | $223M+ |
| JET HEALTH | Healthcare | Provides in-home healthcare, nursing, and therapy | Focus on compassionate care | Significant (not specified) |
| Nacuity Pharmaceuticals | Healthtech | Develops treatments for retinitis pigmentosa (vision disorder) | Part of Fort Worth’s healthtech scene | Millions (not specified) |
1. GenrAb: Saving Brains, One Antibody at a Time
GenrAb is a biotech startup out of UT Southwestern.
They are developing antibody therapies to protect brain cells from stress.
Think diseases like MS and ALS—real, life-changing stuff.
They raised $5.6M in 2025 to push their therapy into clinical trials.
Their tech comes from actual patient spinal fluid.
It is showing promise in animal models.
Why it matters: Neurodegenerative diseases are brutal. GenrAb’s work could change lives.
Tip for founders:
- Focus on a specific problem, like GenrAb does with brain cell damage.
- Partner with universities for credibility and research muscle.
- Secure early funding to prove your concept, then scale.
2. Aerolane
Aerolane is building cargo gliders at Perot Field Fort Worth Alliance Airport.
These AI-powered, electric gliders tackle first-mile and last-mile delivery.
They are cutting costs and emissions for logistics companies.
Why it matters: Supply chain chaos is real. Aerolane’s solution is green and efficient.
Example: Imagine Amazon slashing delivery costs with gliders instead of trucks.
Tip for founders:
- Find a niche in a massive industry like logistics.
- Use AI to automate and optimize—buyers love efficiency.
- Set up shop near key infrastructure, like Aerolane’s airport HQ.
3. Veryable
Veryable is an online marketplace connecting manufacturers with workers.
Companies post tasks; workers bid on them.
It is like Uber for factory jobs, boosting flexibility.
They are scaling fast in DFW’s logistics-heavy market.
Why it matters: Manufacturers need agile labor. Veryable delivers.
Tip for founders:
- Build platforms that solve labor shortages.
- Use AI to match supply and demand, like Veryable’s algorithms.
- Target industries with high turnover for quick adoption.
4. Alto: Luxury Rides, Done Right
Alto is redefining ridesharing with luxury, employee-driven fleets.
No gig drivers here—just vetted, trained pros in well-maintained cars.
They raised $45M in a Series B to go all-electric by 2023.
Now they are expanding beyond DFW to places like D.C.
Why it matters: People want safe, consistent rides. Alto’s nailing it.
Example: Think of Alto as the Tesla of rideshares—premium, reliable, and eco-friendly.
Tip for founders:
- Differentiate by focusing on quality, not just price.
- Invest in branding to stand out in crowded markets.
- Go green to attract investors and customers.
5. StackPath
StackPath offers security solutions for enterprises, from firewalls to SSL certificates.
They serve over a million customers, including Fortune 500 companies.
Their collaborative intelligence tech spots threats fast.
Why it matters: Cybersecurity is non-negotiable. StackPath’s got the edge.
Tip for founders:
- Build scalable solutions for big players.
- Focus on trust—security startups live or die by it.
- Offer add-ons like StackPath’s SSL to boost revenue.
6. Mercado Labs
Mercado Labs is a cloud-based platform for logistics.
It connects suppliers, vendors, and service providers in one hub.
They are improving the first-mile experience for logistics firms.
Why it matters: Last-mile delivery gets all the hype, but first-mile matters too.
Example: Mercado Labs helps companies avoid supply chain nightmares, like delayed shipments.
Tip for founders:
- Solve overlooked problems in big industries.
- Build integrations to make your platform sticky.
- Prioritize user experience for adoption.
7. Zyston
Zyston provides strategic infosec solutions for Fortune 500 companies.
They offer managed SOC services and help protect critical assets.
Their human capital expertise sets them apart.
Why it matters: Big companies need robust security. Zyston delivers.
Tip for founders:
- Specialize in high-value clients, like Fortune 500s.
- Combine tech and human expertise for a killer offering.
- Build long-term contracts for steady revenue.
8. ProsRent (Now BigRentz)
ProsRent is a SaaS platform for construction equipment rentals.
It is a one-stop shop, cutting costs and time for project managers.
They won big at CodeLaunch 2016 for their pitch and financial potential.
Why it matters: Construction is a massive industry. ProsRent streamlines it.
Tip for founders:
- Target industries with fragmented processes, like construction.
- Win pitch competitions for exposure and credibility.
- Focus on customer pain points, like time and cost.
9. Actuate Therapeutics
Actuate Therapeutics, based in Fort Worth, is tackling high-impact cancers and neurodegenerative diseases.
They have raised over $223M in funding.
Their treatments are innovative and showing promise.
Why it matters: Healthtech is a game-changer. Actuate’s in the big leagues.
Example: Their cancer therapies could save lives where others fail.
Tip for founders:
- Go after big problems, like cancer or Alzheimer’s.
- Secure massive funding to scale R&D.
- Build a team of top-tier scientists.
10. JET HEALTH
JET HEALTH provides in-home healthcare, from nursing to therapy.
They focus on compassionate, tailored care.
They have raised significant funding in Fort Worth’s healthtech scene.
Why it matters: Aging populations need quality care. JET HEALTH delivers.
Tip for founders:
- Focus on human-centered solutions in healthcare.
- Build trust through quality and empathy.
- Tap into growing markets, like senior care.
11. Nacuity Pharmaceuticals
Nacuity is working on a breakthrough treatment for retinitis pigmentosa, a vision disorder.
They are part of Fort Worth’s booming healthtech ecosystem.
They’ve raised millions to push their therapy forward.
Why it matters: Vision loss is devastating. Nacuity’s giving hope.
Tip for founders:
- Target niche medical conditions for less competition.
- Partner with research institutions for credibility.
- Focus on patient outcomes to attract investors.
How to Thrive in the DFW Startup Scene
Want to join these startups or start your own? Here’s how to crush it in Dallas-Fort Worth:
- Leverage local resources: Tap into accelerators like Health Wildcatters or Techstars.
- Network like crazy: DFW’s entrepreneur community is tight-knit. Join groups like Dallas Entrepreneur Center.
- Get funded early: Venture capital is flowing—66% growth in recent years.
- Build a strong online presence: Start with a domain from Truehost.com to establish your brand.
- Focus on real problems: Every startup here solves something specific, from brain diseases to logistics.
Example: Vouch, a DFW dating app, made waves by involving friends in matchmaking, solving trust issues in online dating.
Read also: How to Find a Registered Agent for a Corporation in Texas
Final Thoughts
Dallas-Fort Worth is a goldmine for startups.
These 11 companies prove it—solving real problems, raising millions, and scaling fast.
Whether you are a founder or an investor, DFW is where it’s at.
Get your domain on Truehost.com, pick a problem, and start building.
The next big startup could be yours.
Read also:
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- Top #5 Web Hosting Companies in Fort Worth, TX
- #5 Hottest Home Service Niches in the DFW Metroplex
